GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs477692 | 1 | rs477692 | chr10:131426022 | MGMT | chr10:131265454-131565783:+ | 0.25 | 5.43 | 1.02E-7 | Response to temozolomide |
| BLCA | cis | rs34286592 | 1 | rs4788187 | chr16:29845685 | LOC440356 | chr16:29875004-29879374:+ | 0.32 | 3.93 | 0.000102 | Multiple sclerosis |
| BLCA | cis | rs34286592 | 1 | rs4788188 | chr16:29860863 | LOC440356 | chr16:29875004-29879374:+ | -0.33 | -4.03 | 6.67E-5 | Multiple sclerosis |
| BLCA | cis | rs4789693 | 1 | rs4789693 | chr17:80421870 | HEXDC | chr17:80376252-80400515:+ | 0.29 | 6.02 | 4.08E-9 | Glucocorticoid-induced osteonecrosis |
| BLCA | cis | rs8072100 | 1 | rs4794016 | chr17:45725931 | C17orf57 | chr17:45401142-45518675:+ | -0.26 | -5.87 | 9.26E-9 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs8072100 | 1 | rs4794048 | chr17:45763073 | C17orf57 | chr17:45401142-45518675:+ | 0.24 | 5.23 | 2.74E-7 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs4794202 | 1 | rs4794202 | chr17:45930539 | SCRN2 | chr17:45915049-45918699:- | -0.3 | -4.58 | 6.24E-6 | Alzheimer's disease (cognitive decline) |
| BLCA | cis | rs477692 | 1 | rs479478 | chr10:131428959 | MGMT | chr10:131265454-131565783:+ | 0.23 | 5.01 | 8.13E-7 | Response to temozolomide |
| BLCA | cis | rs8078723 | 1 | rs4794823 | chr17:38166265 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.93 | 0.000101 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs8078723 | 1 | rs4795415 | chr17:38157995 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.94 | 9.66E-5 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs8078723 | 1 | rs4795416 | chr17:38158133 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.94 | 9.66E-5 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs8078723 | 1 | rs4795418 | chr17:38164851 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.93 | 0.000101 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -4 | 7.57E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs4803468 | 1 | rs4803463 | chr19:41911040 | B3GNT8 | chr19:41931265-41934635:- | -0.21 | -3.9 | 0.000114 | Height |
| BLCA | cis | rs4803468 | 1 | rs4803468 | chr19:41922352 | B3GNT8 | chr19:41931265-41934635:- | -0.22 | -4.09 | 5.33E-5 | Height |